Mission District Vacations from $296

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Your Mission District Vacation

Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.

The Latest Mission District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Mosser

The Mosser

3 out of 5
Downtown San Francisco
Save 100% on your flight
Price was $490, price is now $296 per person
$296
per person
Mar 4 - Mar 7
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
8/10 Very Good! (1,002 reviews)
there was a dirty bandaid on the floor and the carpet was dirty

Reviewed on Dec 16, 2025

San Carlos Inn

San Carlos Inn

2 out of 5
Save 100% on your flight
Price was $737, price is now $363 per person
$363
per person
Feb 6 - Feb 9
found 7 hours ago
Roundtrip flight included
Carlsbad (CLD) to San Francisco (SFO)
7/10 Good! (316 reviews)
the inn is not a chain and is staff is always friendly . i support local business . I am happy for on site parking near rooms . Glad rooms are street level and no need for stairs/elevator . local motel in downtown dining shopping san carlos area . Am lucky dec 6 last minute reservation . I sheltered here , my job nearby .the inn is small , fits right in the downtown plan ? Bed and pillows above average for me .so is the mini fridge-microwave / heater-ac / cable ,too.

Reviewed on Dec 8, 2025

Montage Healdsburg

Montage Healdsburg

5 out of 5
Save 100% on your flight
Price was $1,954, price is now $1,221 per person
$1,221
per person
Mar 13 - Mar 16
found 9 hours ago
Roundtrip flight included
San Diego (SAN) to San Francisco (SFO)
9.6/10 Exceptional! (113 reviews)
Clean room, kind and helpful staff. Nice ambiance in vineyard.

Reviewed on Nov 30, 2025

Alpine Inn And Suites

Alpine Inn And Suites

2 out of 5
Bayshore Heights
Save 100% on your flight
Price was $1,273, price is now $798 per person
$798
per person
Feb 6 - Feb 9
found 11 hours ago
Roundtrip flight included
Los Angeles (LAX) to San Francisco (SFO)
7.4/10 Good! (1,002 reviews)
Room was spotless. I got into town late. Booked with another hotel and their heater was broken. I booked with Alpine Inn and Suites and they were so anxious to accommodate me. I did not arrive till almost midnight and the front desk stayed up and waited for me! The last hotel was a total dive and upon arrival here I was so relieved and distressed. What a gem! Clean, courteous, and very helpful! Thank you so much!!

Reviewed on Dec 16, 2025

Vinarosa Resort & Spa

Vinarosa Resort & Spa

4 out of 5
Save 100% on your flight
Price was $948, price is now $615 per person
$615
per person
Feb 26 - Mar 1
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.4/10 Exceptional! (794 reviews)
Room was lovely, with views of vineyards. Roomy bathroom, nice fireplace, good bed. Dinner was very good, with excellent service. Overall a great stay.

Reviewed on Nov 29, 2025

Where to stay in Mission District

Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square which includes a high rise building and a city

Union Square

4/5(5,164 area reviews)

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Find hotels in Union Square

Mission District Hotel Deals

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$154 nightly
The price is $181 total per night from Jan 5 to Jan 6
$181 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
8.8/10 Excellent! (7,176 reviews)
Clean room in a very nice hotel. Hotel itself outside of the rooms was quite cool in temperature.

Reviewed on Dec 11, 2025

Hotel Riu Plaza Fisherman's Wharf
Fairmont San Francisco

Fairmont San Francisco

5 out of 5
950 Mason Street Atop Nob Hill San Francisco CA
Fully refundableReserve now, pay when you stay
$260 nightly
The price is $306 total per night from Dec 21 to Dec 22
$306 total
Dec 21 - Dec 22
Total with taxes and fees
9/10 Wonderful! (1,430 reviews)
The Christmas tree - the main highlight of the season - was sadly relegated to the side of the main door and in its usual place was a ridiculous champagne bar! Not a good look for a venerable hotel - and frankly, pretty low-brow. And zero seating in the lobby so everyone was hanging around with their ...

Reviewed on Dec 12, 2025

Fairmont San Francisco
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $140 total per night from Dec 21 to Dec 22
$140 total
Dec 21 - Dec 22
Total with taxes and fees
8.8/10 Excellent! (4,979 reviews)
👍

Reviewed on Dec 16, 2025

Holiday Inn Golden Gateway by IHG
See all 4,902 properties in Mission District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Mission District

Mission Dolores Park showing picnicing and a park as well as a small group of people

Mission Dolores Park

Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.

Mission Dolores Park
Mission San Francisco de Asís was founded 29 June 1776 by Padre Francisco Palóu and Padre Pedro Benito Cambón. The mission is named for Saint Francis of Assisi. The current site was picked in 1782 because of the harsh conditions at the original mission. It is considered to be the oldest intact building in San Francisco. The Mission is located in the San Francisco Mission District at the corner of 16th and Dolores Streets. #Details #golden #troveontuesday #Trovember

Mission San Francisco de Asís

Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the shops and notable monuments in this vibrant area.

Mission San Francisco de Asís
Street level entry overlooking the main lobby.

San Francisco Public Library

After visiting San Francisco Public Library, make a plan to see the other sights and activities in San Francisco. Discover the acclaimed theater scene and notable monuments in this vibrant area.

San Francisco Public Library

Things to do

California Academy of Sciences General Admission

California Academy of Sciences Daytime Admission

$49
per adult
86% of travellers recommend
California Academy of Sciences Daytime Admission
San Francisco City Lights Cruise

San Francisco City Lights Cruise (2-hours)

$58
per adult
94% of travellers recommend
San Francisco City Lights Cruise (2-hours)
Visit de Young Museum in Golden Gate Park

de Young Museum General Admission Ticket

$20
per adult
88% of travellers recommend
de Young Museum General Admission Ticket
See all activities in San Francisco

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.